Indy Best Breakfast

Indy Best Breakfast We conclude that ecDNAs with MYC paralogs are recurrent drivers of cross resistance in SCLC Significance SCLC is initially chemosensitive but acquired cross resistance renders this

Cancers harboring small particles of DNA that exist outside of chromosomes called extrachromosomal DNA ecDNA are associated with aggressive tumor growth drug We demonstrate that cell free nucleosome profiling can noninvasively detect ecDNA amplifications in plasma facilitating its genome wide interrogation in SCLC and other cancers

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These functional profiles captured hallmark clinical features such as the emergence of treatment refractory disease after early relapse Serially derived PDX models The drug resistance in most cancer cells belongs to acquired drug resistance which is gradually produced in the process of chemotherapy As a result the curative effect

These drug response profiles captured hallmark clinical features of SCLC such as the emergence of treatment refractory disease after early relapse For one patient serial PDX models We examined whether ecDNA amplification in tumor cell lines drives ABC transporter overexpression to mediate resistance to paclitaxel a commonly prescribed taxane

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Consequently cross talk between posttranslational modifications facilitate the prevention of DNA damage accumulation within the cancer cell Collectively it is evident that We conclude that ecDNAs with MYC paralogs are recurrent drivers of cross resistance in SCLC SCLC is initially chemosensitive but acquired cross resistance renders

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Small Cell Lung Cancer Acquires Cross resistance Due To

https://cri.utsw.edu › acquired-cross-resistance-in-small-cell-lung...
We conclude that ecDNAs with MYC paralogs are recurrent drivers of cross resistance in SCLC Significance SCLC is initially chemosensitive but acquired cross resistance renders this

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Extrachromosomal DNA Promotes Aggressiveness Of Small Cell

https://ccr.cancer.gov › news › article › extrachromosomal-dna-promotes...
Cancers harboring small particles of DNA that exist outside of chromosomes called extrachromosomal DNA ecDNA are associated with aggressive tumor growth drug

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